Our latest collaborative research on RNA interference (RNAi)-based bioinsecticides has been published in Insect Molecular Biology! This work, conducted in partnership with GreenLight Biosciences, Bayer CropScience, and colleagues from University of Maine, University of Wisconsin, Madison, University of Tennessee, provides critical insights into insect resistance management (IRM) strategies for RNAi-based insecticides.
RNAi bioinsecticides represent a new class of highly targeted and environmentally friendly pest control solutions. However, as with all insecticidal products, the proper implementation of resistance management strategies is crucial to sustaining their effectiveness in the field. Here are the highlights of the paper:
- Differentiated IRM strategies are required for RNAi-based insecticides, depending on whether they are expressed as transgenic traits or applied as sprayable formulations.
- For sprayable RNAi insecticides, such as GreenLight Bio’s Calantha™, rotating applications with other insecticides from different IRAC mode of action groups is recommended to prevent resistance development.
- The paper emphasizes proactive IRM approaches to maintain the efficacy and sustainability of RNAi-based insecticides in integrated pest management programs.
This research contributes to the growing body of knowledge aimed at ensuring that RNAi technology remains a viable and sustainable tool for insect pest control. We are excited to be part of this advancement in biopesticide development.
🔗 Read the full paper here: DOI Link
Authors:
Kenneth Narva, Umut Toprak, Andrei Alyokhin, Russ Groves, Juan Luis Jurat-Fuentes, William Moar, Ralf Nauen, Sean Whipple, Graham Head
